Is Apazone safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Apazone. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels . Four women received apazone 600 mg intravenously within 2 hours postpartum, then twice daily for 5 to 10 days. Apazone was measured in the blood and breastmilk twice between days 4 and 6 postpartum at 4, 8 and 12 hours after the morning dose. The authors calculated that and average of 0.8 mg (range 0.2 to 1.3 mg) of apazone was excreted in milk over a 12-hour dosage interval.[ 2 ] Using reported infant and maternal body weights, a fully breastfed infant would receive an average of 2.13% (range 1.04 to 3.03%) of the mother s weight-adjusted dosage. Infant Levels . Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Apazone is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.