Is Clopidogrel safe while breastfeeding?

Effects on the breastfed infant

Two infants aged 7 to 14 months were partially breastfed by mothers taking clopidogrel 75 mg daily. No adverse health issues were reported for either infant by their mothers.[ 1 ]

Effects on milk supply

Relevant published information was not found as of the revision date.

Levels in milk

Maternal Levels. Milk samples were obtained over a 24-hour period from two nursing mothers who were taking clopidogrel 75 mg daily. In the first patient, milk collections were done at 7 and 9 months postpartum. At 220 days months postpartum, clopidogrel concentrations ranged from 0.03 to 1.11 mcg/L, clopidogrel carboxylic acid concentrations ranged from 1.5 to 22.44 mcg/L and clopidogrel active metabolite concentrations were below the limit of quantification ( 0.008 mcg/L). At 288 days postpartum, clopidogrel concentrations ranged from 0.42 to 10.46 mcg/L, clopidogrel carboxylic acid concentrations ranged from 1.25 to 36.32 mcg/L and clopidogrel active metabolite concentrations were below the limit of quantification ( 0.008 mcg/L) in 5 samples and 0.18 mcg/L in 1 sample. In the second patient, milk samples taken at 435 days postpartum, clopidogrel concentrations ranged from 0.02 to 1.69 mcg/L, clopidogrel carboxylic acid concentrations ranged from 1.43 to 26.96 mcg/L and clopidogrel active metabolite concentrations were below the limit of quantification ( 0.008 mcg/L). Relative infant dosages averaged 0.008% for clopidogrel and 0.071% when the two metabolites were included.[ 1 ] Infant Levels. An infant aged 14 months was partially breastfed by a mother taking clopidogrel 75 mg daily. A blood sample was obtained from the infant. The concentrations in the infant blood sample were clopidogrel 0.01 mcg/L, CAMD 0.01 mcg/L, and clopidogrel carboxylic acid 0.05 mcg/L.[ 1 ]

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