Is Cycloserine safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Cycloserine. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
No adverse effects were noted in 5 in breastfed infants (ages not stated) whose mothers were taking oral cycloserine 250 mg 4 times daily.[ 1 ] Cycloserine was used as part of multi-drug regimens to treat 5 women with multidrug-resistant tuberculosis, 4 throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 1.25, 1.8, 3.9, 4.6 and 5.5 years, the children were developing normally except for a mild speech delay in one and hyperactivity in another.[ 4 ]
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. In 5 women (time postpartum not stated) receiving oral cycloserine 250 mg 4 times daily, single milk levels from each of the mothers (collection times not stated) averaged 13.4 mg/L (range 6 to 19 mg/L).[ 1 ] It is estimated that a fully breastfed infant would receive 1.7 mg/kg daily or 11 to 28% of a usual infant dosage.[ 2 , 3 ] Infant Levels. Relevant published information was not found as of the revision date.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.