Is Diflunisal safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Diflunisal. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels . Review articles report that milk levels are 2 to 7% of simultaneous maternal serum levels after 7 days of administration of 125 or 250 mg twice daily; however, no study details are provide.[ 1 , 2 ] This would represent milk levels ranging from 0.3 to 0.9 mg/L with a dose of 125 mg daily and 0.8 to 2.7 mg/L with a dose of 250 mg daily. Infant Levels . Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Diflunisal is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.