Is Gabapentin safe while breastfeeding?

Effects on the breastfed infant

Three infants who were 2 to 3 weeks of age and one who was 14 weeks of age were breastfed during maternal use of gabapentin in an average daily dosages of 1575 mg (range 600 mg to 2.1 grams daily). One infant's mother was also taking topiramate and lorazepam and another infant's mother was taking clonazepam. No adverse effects were noted in any of the infants.[ 3 ] A follow-up publication by the same authors found no adverse reactions among 3 additional breastfed infants whose mothers were taking gabapentin during pregnancy and lactation.[ 4 ] An exclusively breastfed 5-day-old infant whose mother was taking gabapentin 1.2 grams and levetiracetam 2.5 grams daily during pregnancy and lactation appeared healthy to the investigators throughout the 6- to 8-week study period.[ 7 ] An infant whose mother was taking gabapentin 36.7 mg/kg daily breastfed her infant 6 to 7 times daily for most of the first 1.6 months of life with some additional artificial feeding at night. The mother was also taking amitriptyline 2.5 mg daily. At 1.6 months of age, the infant was found to be healthy with a weight between the 10th and 25th percentiles, having been at the 50th percentile at birth. His age on the Denver developmental test was the same as his chronological age.[ 5 ]

Effects on milk supply

Relevant published information was not found as of the revision date.

Levels in milk

In published reports of anticonvulsant use during breastfeeding, most women were taking a combination of anticonvulsants. Some other anticonvulsants (e.g., phenytoin, carbamazepine) stimulate the metabolism of other drugs including anticonvulsants, whereas others (e.g., valproic acid) inhibit the metabolism of other drugs. Therefore, the relationship of the maternal dosage to the concentration in breastmilk can be quite variable, making calculation of the weight-adjusted percentage of maternal dosage less meaningful than for other drugs in this database. Maternal Levels. Four women who were taking gabapentin and were 12 to 21 days postpartum and a fifth who was 97 days postpartum had a single breastmilk sample measured just before nursing 10 to 15 hours after the previous evening's dose. Their average dosage of 1.5 grams daily (range 0.6 to 2.1 grams daily) and their average milk level was 4.5 mg/L (range 1.2 to 8.7 mg/L). The authors estimated that a fully breastfed infant would receive a dosage of 0.2 to 1.3 mg/kg daily at the minimum which is equivalent to 1.3 to 3.8% of the maternal weight-adjusted dosage.[ 3 ] A follow-up publication by the same authors found a similar degree of gabapentin excretion into breastmilk in 8 breastmilk samples from 3 additional mothers.[ 4 ] A woman took gabapentin 600 mg 3 times daily (36.7 mg/kg daily) plus amitriptyline 2.5 mg daily for 6 weeks beginning in the first few days postpartum for chronic back pain. Eight milk samples (6 foremilk and 2 hindmilk) were obtained over 24 hours. Milk levels varied between about 5 and 7 mg/L. Using the average milk level, a fully breastfed infant would receive a dosage of 0.86 mg/kg daily or 2.34% of the maternal weight-adjusted dosage.[ 5 ] Twenty-six women undergoing a cesarean section received a single 300 mg oral dose of gabapentin preoperatively, followed by 300 mg oral doses every 6 hours for the first 48 hours after delivery as part of a standard analgesia protocol. Maternal plasma was

Alternatives LactMed lists

• Divalproex
• Lamotrigine
• Oxcarbazepine
• Phenytoin
• Valproic Acid