Is Lumateperone safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Lumateperone. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. The manufacturer reports a lactation study in 17 lactating women that evaluated the concentrations of lumateperone and its metabolites in plasma and mature breast milk following a single dose of 42 mg of lumateperone. The estimated daily infant dose of lumateperone in human milk was 0.0004 mg/kg (with assumed average daily milk consumption of 200 mL/kg). The mean relative infant dose (with an assumed mean daily milk consumption of 200 mL/kg and average maternal weight of 71 kg) was 0.06% of the maternal weight-adjusted dosage. Several major circulating metabolites were also present in breastmilk at estimated daily infant dose of 0.0004 mg/kg. Aniline metabolites were not detectable in milk or maternal plasma at quantifiable levels. Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Lumateperone is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.