Is Mebufotenin safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Mebufotenin. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. In a preliminary study on the use of mebufotenin for postpartum depression, patients were administered an individualized dosing regimen of up to three escalating doses of mebufotenin (6, 12, and 18 mg) on a single day by pulmonary inhalation. Of the four lactating patients, three received mebufotenin 6 + 12 mg and one received mebufotenin 6 + 12 + 18 mg. Concentrations of mebufotenin, its psychoactive metabolite bufotenin, and its non-psychoactive metabolite 5-methoxyindole- 3-acetic acid (5-MIAA) were measured in breastmilk. Mebufotenin levels in breastmilk ranged from 0.24 to 3.11 mcg/L at 1 hour post-dose, from below the limit of quantification (BLQ) to 0.56 mcg/L at 2.5 hours post-dose, and from BLQ to 0.04 mcg/L at about 8 hours after the dose; all levels were BLQ on days 2 and 8. Bufotenin was BLQ in breastmilk at all time points. 5-MIAA levels were 13.9 to 28.5 mcg/L at 1 hour post-dose, 8.1 to 13.5 mcg/L at 2.5 hours after the dose, BLQ to 0.90 mcg/L at about 8 hours after the dose, BLQ to 0.22 mcg/L on day 2, and BLQ on day 8.[ 1 ] Infant Levels. Relevant published information was not found as of the revision date.
“No published information” means the studies do not exist yet — not that Mebufotenin is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.