Is Prucalopride safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Prucalopride. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. The manufacturer reports an unpublished study in 8 healthy lactating women who were weaning their infants and given prucalopride 2 mg daily for 4 days. Plasma and milk samples were collected at predose (day 1 and 4), and at 2, 4, 8, 12, and 24 hours after the dose on day 4. The dose to the breastfed infant was estimated to be 1.74 mcg/kg daily, which is about 6% of the weight-adjusted maternal dose. Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Prucalopride is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.