Is Rubella Vaccine safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Rubella Vaccine. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Limited data indicate that breastfeeding can enhance the response of the infant to certain vaccine antigens.[ 2 , 11 ] A paper reported on 511 women who received rubella vaccine in the immediate postpartum period. Three strains were studied: Cendehill (n = 210), HPV-77 DE-5 (Meruvax; n = 182) and RA 27/3 (n = 119). Sixty-three infants, 67% of whom were breastfed, were studied at 2 to 8 months of age. None of them had any evidence of side effects or seroconversion from maternal vaccination.[ 12 ] One 12-day-old breastfed infant developed a rubella infection 11 days after maternal vaccination with live rubella vaccine.[ 13 ] However, it is questionable if maternal vaccination was the cause of the infant's infection.[ 14 ] Another breastfed infant had live rubella vaccine virus isolated from a throat swab after maternal immunization. The infant did not demonstrate seroconversion or adverse reactions.[ 7 ] Some breastfed infants acquire passive immunity to rubella after maternal vaccination as do infants of mothers with natural rubella immunity. However, neither group of infants has a decreased response to rubella vaccine administered to the infant at 15 to 18 months of age.[ 8 ] After immunization of their mothers with rubella vaccine, 25% of breastfed infants in one study showed transient seroconversion to rubella virus (RA 27/3 strain), but without any clinical disease.[ 9 ]
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Early studies found no transmission of rubella virus to breastfed infants. None of 18 infants who were breastfed after maternal vaccination with rubella vaccine (various strains) had detectable antibodies in one study.[ 4 ] Another study of two strains of rubella vaccine (HPV -77 DE5 and RA 27 /3) given by subcutaneous injection or intranasal inhalation found infectious rubella virus or virus antigen in the breastmilk of 8 of the 13 women.[ 5 ] A study of mothers vaccinated with the Cendehill strain of live, attenuated rubella virus found no transmission of the live virus to their breastfed infants.[ 6 ] However, rubella vaccine virus can appear in breastmilk and result in infections in some infants.[ 7 - 9 ] See "Effects In Breastfed Infants" below. In a prospective study, 169 mothers with low titers or either measles or rubella were given MR vaccine (Schwarz FF-8 strain/TO-336 strain; Takeda Pharmaceutical Co. Ltd, Osaka, Japan) at their 1-month postnatal checkup. Mothers provided 5 mL of breastmilk 2 weeks later. Rubella virus antigen was not detected in the breastmilk of any mothers.[ 10 ] Infant Levels. Relevant published information was not found as of the revision date.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.