Is Sacubitril safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Sacubitril. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Two women taking sacubitril 24 mg and valsartan 26 mg (Entresto) did not observe any symptoms in their breastfed infants. Their extent of breastfeeding was not reported.[ 1 ]
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Five mothers taking sacubitril 24 mg and valsartan 26 mg (Entresto) twice daily collected milk samples at 0, 1, 2, 4, 6, 8, 10, and 12 hours after taking a dose at steady state. The peak sacubitril milk concentration of 12.2 mcg/L occurred at 1 hour after the dose. Its average concentration was 0.497 mcg/L. The peak LBQ657 milk concentration of 1.52 mcg/L occurred at 4 hours after the dose. Its average concentration was 9.5 mcg/L. Calculated infant dosages of sacubitril and its metabolite were 0.98 mcg/kg and 1.42 mcg/kg daily, which translate into 0.01% and 0.22%, respectively.[ 1 ] Infant Levels. Relevant published information was not found as of the revision date.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.