Is Sargramostim safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Sargramostim. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Twenty nursing mothers of full-term infants provided milk samples at 5 days postpartum. The average concentration of GM-CSF in their milk was 100 ng/L.[ 3 ] A woman with autoimmune pulmonary alveolar proteinosis caused by GM-CSF autoantibodies was treated with inhaled sargramostim 250 mcg daily. GM-CSF was undetectable in milk both before and 8 hours after receiving inhaled sargramostim.[ 4 ] Infant Levels. Twenty breastfed and 13 formula-fed full-term infants had serum concentration of GM-CSF measured at 5 days of age. Breastfed infants had an average GM-CSF concentration of 33.5 ng/L and formula-fed infants had an average GM-CSF serum concentration of 18.9 ng/L, but this difference was not statistically significant. In addition, no difference was found in neutrophil chemotaxis between the two groups and no correlations were found between GM-CSF concentrations in milk or infants' sera and neutrophil chemotaxis.[ 3 ]
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.