Is Sirolimus safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Sirolimus. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
One infant was reported breastfed (extent not stated) during maternal therapy with sirolimus, tacrolimus and prednisone in unspecified dosages following a kidney-pancreas transplant. The authors who followed the mother knew of no serious side effects in the infant.[ 1 ] A review of the Transplant Pregnancy Registry International database from 1999 to 2024 found that 4 mothers with transplants had breastfed their infants for at least 4 weeks while taking sirolimus.[ 2 ]
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels . Relevant published information was not found as of the revision date. Infant Levels . Relevant published information was not found as of the revision date.
Alternatives LactMed lists
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.