Is Zavegepant safe while breastfeeding?
Here is what NIH LactMed, the U.S. National Library of Medicine's authority on medicines and breastfeeding, reports about Zavegepant. This is a summary of that source — not our own verdict.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Twelve healthy lactating women who were at least 2 weeks postpartum were give a single intranasal dose of 10 mg of zavegepant. Milk samples were taken before the dose and at 0 to 2, 2 to 4, 4 to 6, 6 to 8, 8 to 12, 12 to 16, and 16 to 24 hours after the dose. The median peak milk concentration was 1.10 mcg/L and the geometric mean peak concentration was 0.77 mcg/L at a median of 4.83 hours after the dose. The estimated infant daily dosage was 0.05 to 0.06 mcg/kg, which resulted in an RID of 0.04 to 0.05%.[ 1 ] Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Zavegepant is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: NIH LactMed (National Library of Medicine).
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.